Skip to main content

New top story from Time: Moderna Is Testing a New Version of Its COVID-19 Vaccine That Wouldn’t Require Ultra-Cold Storage

https://ift.tt/3t33uU6

As safety concerns over COVID-19 vaccines from AstraZeneca and Johnson&Johnson–Janssen have led to disruptions in the inoculation efforts of numerous countries relying on those shots, companies like Moderna are attempting to fill the resulting gaps.

The Massachusetts-based biotech company announced on April 29 that it is investing billions to boost manufacturing facilities in Switzerland, Spain and the U.S., building enough capacity to produce up to 3 billion doses of its mRNA-based vaccine through 2022. The company’s vaccine technology differs from that of AstraZeneca and J&J, which both use an adenovirus to deliver COVID-19 virus genes to the immune system—and which both have been have been associated with serious, life-threatening—albeit very rare—blood clots.

Stephane Bancel, CEO of Moderna, says that some of the wealthier, developed countries are eager to up their orders of the mRNA vaccines (which include both the Moderna shot and one produced by Pfizer/BioNTech). “In the last month or so, in the discussions we have had with heads of state, prime ministers, presidents of countries and health ministers, when governments look at efficacy, safety, manufacturing scalability, and the speed to the next generation of vaccines, what we are hearing loud and clear is that mRNA is the best for the problem at hand,” says Bancel. “And governments around the world want more and more mRNA product.”

To meet that need, and the needs of facilities in less-resourced countries that don’t have the freezer capabilities required to store the company’s vaccine currently, Bancel says that his scientists are studying a new version of the Moderna vaccine that won’t need to be frozen, and instead would simply need to be kept under refrigerated conditions for up to three months. Right now, it can only be stored at those temperatures for one month after the doses are thawed from their frozen storage temperature of about -20°C (14°F)—which requires special equipment that is not widely available. If the studies show the new vaccine could be stable and efficacious at refrigerated temperatures, that could increase the number of places that could vaccinate with Moderna’s shot.

“We played with a couple of key technological decisions and it is indeed a very different product,” says Bancel about the refrigerated version, which the company has just started testing in people. That means efficacy data won’t be available until the end of summer at the earliest; the company is working with the FDA to figure out what the authorization process would look like for that vaccine.

Meanwhile, the company is also studying three new versions of its COVID-19 vaccine to address viral mutations. One is specifically designed to protect against a more infectious variant of the virus, B.1.351, first identified in South Africa. The current Moderna vaccine has been shown in studies to bestow sufficient protection against this variant, but that protection is slightly lower than that provided against the original viral strain, and Moderna researchers are testing if the new shot activates a stronger immune response against the B.1.351 variant. Studies in animals are promising and human studies have just begun, so by early fall, says Bancel, “we expect the data [for the new vaccine] in humans to be as strong as what we saw last year with the current vaccine.”

The Moderna team is also testing whether a third shot of its currently authorized vaccine—at a lower dose than the first and second shots—could be effective as a booster, to increase protection against variant strains. And finally, the company is also testing a vaccine that combines the original vaccine with the new one against the South African variant.

Looking ahead, some public health experts believe controlling COVID-19 may require regular vaccinations, similar to flu shots, to maintain immune protection. Anticipating that, Moderna scientists are also working on a combined flu and COVID-19 shot that would protect people against both respiratory diseases.

Comments

Popular posts from this blog

FOX NEWS: Americans will suffer 5 sweaty, sleepless nights before turning on the AC for the summer, survey finds Nearly half of Americans wouldn’t date someone who didn’t have the same thermostat etiquette as them, according to new research.

Americans will suffer 5 sweaty, sleepless nights before turning on the AC for the summer, survey finds Nearly half of Americans wouldn’t date someone who didn’t have the same thermostat etiquette as them, according to new research. via FOX NEWS https://ift.tt/2Ay0ABA

New top story from Time: A COVID Outbreak Sparked by Partying Teens Leads to 5,000 Being Quarantined in Spain

https://ift.tt/2UJaeL7 MADRID — Almost 5,000 people are in quarantine after vacationing high school students triggered a major COVID-19 outbreak on the Mediterranean island of Mallorca, a senior official said Monday. Authorities have confirmed almost 1,200 positive cases from the outbreak, Spain’s emergency health response coordinator, Fernando Simón said. The partying teens celebrating the end of their university entrance exams last week created a “perfect breeding ground” for the virus as they mixed with others from around Spain and abroad, Simón told a news conference. Mallorca health authorities carried out mass testing on hundreds of students after the outbreak became clear. It is believed to have spread as hundreds of partying students gathered at a concert and street parties. Officials have so far traced 5,126 travelers to Mallorca. More than 900 COVID-19 cases in eight regions across mainland Spain have been traced back to the outbreak. Scores of infected teens are...

PM Modi lauds IFS officers for their work towards serving nation, furthering national interests https://ift.tt/36HoEzw

Greeting Indian Foreign Service officers on IFS day, Prime Minister Narendra Modi on Friday said that their work towards serving the nation and furthering national interests globally are commendable. Their efforts during the Vande Bharat Mission, which was launched to bring Indians home from abroad during the COVID-19 pandemic as international travel came to a halt, and other related help to our citizens and other nations is noteworthy, Modi added.

New Sculptures Light up Van Ness Avenue

New Sculptures Light up Van Ness Avenue By Luis “Loui” Apolonio Light sculpture at Van Ness Avenue and O'Farrell Street Spectators gathered both online and in person to watch new lighting sculptures on Van Ness turned on for the first time on March 31, 2022. The whimsical and brightly colored sculptures located on the new Van Ness BRT boarding platform between Geary and O’Farrell are made of steel with LED lights inside on a timer set to illuminate at night.  The lighting event was kicked off with SFMTA Director Jeff Tumlin and MTAB Chair Gwyneth Borden serving as emcees. Mary Chou, Director of Public Arts and Collections at the San Francisco Arts Commission, spoke about the art installation itself, as well as the process for selecting the artist who would be awarded the project. In addition, Maddy Ruvolo, a member of the SFMTA’s Accessible Services team and a recently appointed member of President Biden’s U.S. Access Board, shared the importance of having accessibility as a ...

Happy Lunar New Year 2022: Year of the Tiger 

Happy Lunar New Year 2022: Year of the Tiger  By Pamela Johnson Lunar New Year is one of the biggest holidays celebrated in many Asian communities. Diverse San Franciscan communities including Chinese, Japanese, Korean, and Vietnamese people have long celebrated this festive occasion.  For many, the Lunar New Year brings a fresh mindset and resolutions for happiness and health. A zodiac animal with specific traits represents each year in the repeating zodiac cycle of 12 years. 2022 is the Year of the Tiger, the third animal in the zodiac. The tiger is considered courageous and adventurous.   The holiday follows the moon's cycles and usually begins in late January or early February. This year Lunar New Year begins February 1.   Fun Fact: In the lunar calendar, the Vietnamese zodiac and the Chinese zodiac are similar, but the Vietnamese zodiac includes a cat while the Chinese ...

New T Third Connecting Chinatown to Sunnydale Starts Saturday

New T Third Connecting Chinatown to Sunnydale Starts Saturday By Christopher Ward New Muni Metro map. This Saturday the T Third starts its long-awaited new route connecting Chinatown-Rose Pak Station from 4th & King in Central Subway, Mondays through Fridays, 6 a.m. to midnight every 10 minutes and Saturdays and Sundays, 8 a.m. to midnight every 12 minutes.   The K Ingleside will now travel between Balboa Park and Embarcadero Station. Customers using Embarcadero & Folsom, Embarcadero & Brannan and 2nd and King platforms should transfer to the N Judah at Powell Station or 4th & King. Watch the new Muni Metro service  map animations . The following bus service changes also start this Saturday: The T Third Bus will now run along 3rd and 4th Streets in SoMa and on Stockton Street north of Market Street to align with the new T Third rail line and will no longer travel on the Embarcadero and Market Street.   The 6 Haight/Parnassus  will now...

FOX NEWS: Couple gets married at 'most beautiful' Taco Bell: 'It was the best of both worlds' Analicia Garcia, 24, and Kyle Howser, 25, from Sacramento, California, got married on Tuesday, Oct. 26 and had their reception at the famous Pacifica, California, Taco Bell.

Couple gets married at 'most beautiful' Taco Bell: 'It was the best of both worlds' Analicia Garcia, 24, and Kyle Howser, 25, from Sacramento, California, got married on Tuesday, Oct. 26 and had their reception at the famous Pacifica, California, Taco Bell. via FOX NEWS https://ift.tt/iznRBtFTJ

New top story from Time: ‘It’s a Catastrophe.’ Iranians Turn to Black Market for Vaccines as COVID-19 Deaths Hit New Highs

https://ift.tt/3AODY94 In January, Iranian Supreme Leader Ayatollah Ali Khamenei made the sudden announcement that American and British-made COVID-19 vaccines would be “forbidden” as they were “completely untrustworthy.” Almost nine months later, Iran is facing its worst surge in the virus to date — a record number of deaths and infections per day with nearly 4.2 million COVID-19 patients across the country , and a healthcare system near collapse. “It’s a catastrophe; and there is nothing we can do,” said an anesthesiology resident in one of Tehran’s public hospitals who due to the current surge is tasked to oversee the ICU ward for COVID-19 patients. “We can’t treat them nor help them; so all I can ask people to do is to stay home and do whatever it takes to not get exposed.” The doctor requested anonymity in order to speak freely; others interviewed by TIME asked to be identified only by their first name. [time-brightcove not-tgx=”true”] The scale of the crisis is such ...

Smarter Traffic Signals Prioritize Transit and People

Smarter Traffic Signals Prioritize Transit and People By Robert Lim Have you ever wondered how traffic signals could better balance the needs of all road users, whether driving, bicycling, walking or taking Muni? The SFMTA is rolling out its Connected Corridor Pilot this month to use transit platform and traffic signal sensor data to inform signal timing adjustments. The pilot also aims to collect information to support transit efficiency and street safety improvements.  Traffic engineers use signal timing adjustments as a tool to prioritize the flow of travel in specific directions or for different travel modes – Muni, people walking or driving – to meet the changing demands of the road network across different timepoints in a day. The Connected Corridors Pilot seeks to push the envelope of innovation by investing in advanced technologies, funded through a U.S. Department of Transportation (USDOT) grant. These tools will better position the city to serve the potential future ne...

Sunday Streets Returns October 17, with Phoenix Day

Sunday Streets Returns October 17, with Phoenix Day By Pamela Johnson For 13 years, the SFMTA and Livable City have brought "Sunday Streets" to San Francisco neighborhoods. Sunday Streets encourages communities to transform miles of car-congested streets into car-free spaces for neighbors to gather, kids to play, and for organizations and businesses to connect. On October 17, 2021, after more than 18 months of Covid-related shutdowns, Sunday Streets Phoenix Day will again bring free recreational activities, resources, and fun to the streets for tens of thousands of San Franciscans to enjoy. While Sunday Streets was celebrated in one neighborhood at a time in the past, this year's Phoenix Day spans various districts in the City for a simultaneous celebration of community, health, and resilience. This year's theme is "One City. One day. Rising together.”  Highlights this year include historic Sunday Streets SF routes, a 20+ mile community bike ride, three neighb...