Skip to main content

New top story from Time: Moderna Is Testing a New Version of Its COVID-19 Vaccine That Wouldn’t Require Ultra-Cold Storage

https://ift.tt/3t33uU6

As safety concerns over COVID-19 vaccines from AstraZeneca and Johnson&Johnson–Janssen have led to disruptions in the inoculation efforts of numerous countries relying on those shots, companies like Moderna are attempting to fill the resulting gaps.

The Massachusetts-based biotech company announced on April 29 that it is investing billions to boost manufacturing facilities in Switzerland, Spain and the U.S., building enough capacity to produce up to 3 billion doses of its mRNA-based vaccine through 2022. The company’s vaccine technology differs from that of AstraZeneca and J&J, which both use an adenovirus to deliver COVID-19 virus genes to the immune system—and which both have been have been associated with serious, life-threatening—albeit very rare—blood clots.

Stephane Bancel, CEO of Moderna, says that some of the wealthier, developed countries are eager to up their orders of the mRNA vaccines (which include both the Moderna shot and one produced by Pfizer/BioNTech). “In the last month or so, in the discussions we have had with heads of state, prime ministers, presidents of countries and health ministers, when governments look at efficacy, safety, manufacturing scalability, and the speed to the next generation of vaccines, what we are hearing loud and clear is that mRNA is the best for the problem at hand,” says Bancel. “And governments around the world want more and more mRNA product.”

To meet that need, and the needs of facilities in less-resourced countries that don’t have the freezer capabilities required to store the company’s vaccine currently, Bancel says that his scientists are studying a new version of the Moderna vaccine that won’t need to be frozen, and instead would simply need to be kept under refrigerated conditions for up to three months. Right now, it can only be stored at those temperatures for one month after the doses are thawed from their frozen storage temperature of about -20°C (14°F)—which requires special equipment that is not widely available. If the studies show the new vaccine could be stable and efficacious at refrigerated temperatures, that could increase the number of places that could vaccinate with Moderna’s shot.

“We played with a couple of key technological decisions and it is indeed a very different product,” says Bancel about the refrigerated version, which the company has just started testing in people. That means efficacy data won’t be available until the end of summer at the earliest; the company is working with the FDA to figure out what the authorization process would look like for that vaccine.

Meanwhile, the company is also studying three new versions of its COVID-19 vaccine to address viral mutations. One is specifically designed to protect against a more infectious variant of the virus, B.1.351, first identified in South Africa. The current Moderna vaccine has been shown in studies to bestow sufficient protection against this variant, but that protection is slightly lower than that provided against the original viral strain, and Moderna researchers are testing if the new shot activates a stronger immune response against the B.1.351 variant. Studies in animals are promising and human studies have just begun, so by early fall, says Bancel, “we expect the data [for the new vaccine] in humans to be as strong as what we saw last year with the current vaccine.”

The Moderna team is also testing whether a third shot of its currently authorized vaccine—at a lower dose than the first and second shots—could be effective as a booster, to increase protection against variant strains. And finally, the company is also testing a vaccine that combines the original vaccine with the new one against the South African variant.

Looking ahead, some public health experts believe controlling COVID-19 may require regular vaccinations, similar to flu shots, to maintain immune protection. Anticipating that, Moderna scientists are also working on a combined flu and COVID-19 shot that would protect people against both respiratory diseases.

Comments

Popular posts from this blog

Bihar: Stages collapse during Congress rallies in Darbhanga, West Champaran https://ift.tt/37QFnks

The stage on which Congress candidate from Jale assembly seat, Mashkoor Ahmad Usman was addressing a rally broke and collapsed in Bihar's Darbhanga on Thursday. In a similar incident, another stage collapsed and took down party leaders Imran Pratapgarhi and Akhilesh Singh along with several party workers who were on the dias, during a Congress rally at Bagahi Deoraj in Champaran.

New Dashboards Give a Window into Muni Service Changes

New Dashboards Give a Window into Muni Service Changes By Kate McCarthy An inspector manages Muni service. New dashboards that help inform changes to Muni service are now live at SFMTA.com/MuniData Many factors inform our decisions about Muni service adjustments. These include making sure changes to service support the SFMTA’s values, which are economic vitality, environmental stewardship, trust and equity. We also evaluate travel patterns. You can now explore these patterns using the new Muni data dashboards  (SFMTA.com/MuniData). When looking at possible Muni service changes, the first thing we do is turn to the Muni Service Equity Strategy for guidance. Using the Muni Service Equity Strategy, we prioritize providing Muni service along routes that more often serve people of color, members of low-income households, and/or those who are dependent upon transit service, including people with disabilities and seniors. We also use ridership data to analyze where riders are boa...

India reports first 6 cases of new coronavirus strain after UK returnees test positive https://ift.tt/3pA0T2j

India on Tuesday reported the first six cases of the new coronavirus strain after six people who had returned from the United Kingdom were tested positive for the new UK variant genome. According to the details, the new coronavirus strain cases were reported from Hyderabad, Pune and Bangalore. Samples of 3 UK returnees were tested and found positive for the new UK strain in NIMHANS, Bengaluru. The other two cases were tested at the Centre for Cellular and Molecular Biology, Hyderabad; while the last case was tested at the National Institute of Virology, Pune.

FOX NEWS: Ohio amusement park shut down after multiple fights break out Kings Island in Mason, around 20 miles north of Cincinnati, closed down 30 minutes early Saturday night after several fights among teenagers occurred, reports suggest.

Ohio amusement park shut down after multiple fights break out Kings Island in Mason, around 20 miles north of Cincinnati, closed down 30 minutes early Saturday night after several fights among teenagers occurred, reports suggest. via FOX NEWS https://ift.tt/3wsn8uI

PM Modi lauds IFS officers for their work towards serving nation, furthering national interests https://ift.tt/36HoEzw

Greeting Indian Foreign Service officers on IFS day, Prime Minister Narendra Modi on Friday said that their work towards serving the nation and furthering national interests globally are commendable. Their efforts during the Vande Bharat Mission, which was launched to bring Indians home from abroad during the COVID-19 pandemic as international travel came to a halt, and other related help to our citizens and other nations is noteworthy, Modi added.

FOX NEWS: Bride's father asks stepdad to help walk her down the aisle in sweet viral moment A selfless gesture by the father of a bride was shared on social media in a viral moment of him surprising the girl’s stepfather by asking him to help walk her to the altar.

Bride's father asks stepdad to help walk her down the aisle in sweet viral moment A selfless gesture by the father of a bride was shared on social media in a viral moment of him surprising the girl’s stepfather by asking him to help walk her to the altar. via FOX NEWS https://ift.tt/ZkQ1Rpt

Better Connections from Bayview and Hunters Point to Downtown

Better Connections from Bayview and Hunters Point to Downtown By Enrique Aguilar To better connect southeast San Franciscans with downtown, the SFMTA debuted the 15 Bayview Hunters-Point Express in late January, coinciding with the return of T Third train service. Within weeks, average daily boardings reached 1,000 customers on this new service. The 15 Bayview Hunters Point Express  We added this route based on community feedback from the Southeast Muni Expansion Project in 2018, which prioritized a more direct trip to downtown from the Bayview. With the sudden rise of the COVID-19 pandemic and its disproportionate impacts on communities in the Bayview and Hunters Point, fast-tracking the project became critical to our transit planning. Adding service capacity and a direct connection between these neighborhoods and downtown is a crucial step in supporting the City’s economic recovery and increasing job access for essential workers using transit. Using data from the SFMTA Equ...

Plan Your Next Golden Gate Park Trip with Muni

Plan Your Next Golden Gate Park Trip with Muni By Eillie Anzilotti   A map of San Francisco showing Muni lines that offer direct service to Golden Gate Park, including: The 18 46th Avenue, the 29 Sunset, the 5 Fulton and 5R Fulton Rapid, the N Judah, the 44 O’Shaughnessy, the 33 Ashbury/18th Street, the 7 Haight/Noriega, the 43 Masonic and the 28 19th Avenue. Around each bus route shown on the map, a red zone shows the range within 1,000 feet of a stop, orange shows within 2,000 feet of a stop, and yellow shows within 3,000 feet. Here’s a fun fact: 70% of San Franciscans are within a 15-minute walk of a transfer-free Muni ride to the largest public space in our city: Golden Gate Park.   Especially as COVID-19 has heightened the importance of outdoor recreation and park access, SFMTA has made efforts to update Muni service to get people to Golden Gate Park. As of now, ...

New top story from Time: ‘I Should Be Presumed Innocent.’ Hong Kong Media Tycoon Jimmy Lai Criticizes His Arrest

https://ift.tt/342b8VJ Hong Kong media tycoon Jimmy Lai said he was arrested on “trumped up” charges, pushing back against landmark national security legislation that has raised questions about press freedoms and the future of the democracy movement. “They’re trumped up. I can’t go further on the details,” Lai said in an interview with Bloomberg Television on Friday morning. “Before any evidence, they just claimed and presumed that I’m guilty. This isn’t the way the law is. I should be presumed innocent. We have never supported the independence of Hong Kong.” He said Hong Kong’s future as Asia’s main financial hub was uncertain if there was no respect for the rule of law under the new security measures. “The future of Hong Kong is the future of any other Chinese city,” he added. “Without the rule of law, the international financial center will be finished.” He added that the law sent a “very negative” message to the business community in Hong Kong and overseas. Lai has ...

अगर मैंने आत्महत्या की तो लोगों को पता होना चाहिए किसकी वजह से की - फूटकर रोते दिखे विकास गुप्ता

सुशांत सिंह राजपूत की आत्महत्या हर किसी को एक गहरा सदमा दे गई है और अब सुशांत के करीबी दोस्त विकास गुप्ता ने एक वीडियो में अपनी आपबीती सुनाई है। विकास इस वीडियो में बेहद टूटे हुए नज़र आ रहे हैं from टेलीविजन की खबरें | Television News in Hindi | TV Serials Update in Hindi – FilmiBeat Hindi http:/hindi.filmibeat.com/television/vikas-gupta-reveals-people-want-him-to-commit-suicide-cries-his-heart-out-for-sushant-singh-rajput-090284.html?utm_source=/rss/filmibeat-hindi-television-fb.xml&utm_medium=23.213.205.12&utm_campaign=client-rss